Research Papers

This database includes peer-reviewed publications authored or funded by TB Alliance. Use the tags on the right to filter by subject, or search for a particular author or term using the search bar.

Displaying 191 papers

A comparison of liquid and solid culture for determining relapse and durable cure in phase III TB trials for new regimens

12/2017 - BMC Medicine 2017 15:207

Author(s): Patrick P. J. Phillips, Carl M. Mendel, Andrew J. Nunn, Timothy D. McHugh, Angela M. Crook, Robert Hunt, Anna Bateson and Stephen H. Gillespie

Tags: Clinical Trial Results, ReMoxTB

Synthesis and evaluation of analogues of the tuberculosis drug bedaquiline containing heterocyclic B-ring units

10/2017 - Bioorganic & Medicinal Chemistry Letters

Author(s): Peter Choi, Hamish Sutherland, Amy S.T.Tong, Adrian Blaser, Scott Franzblau, Christopher B.Cooper, Manisha U.Lotlikar, Anna M.Upton, Jerome Guillemont, Magali Motte, Laurence Queguiner, Koen Andries, Walter Van den Broeck, William A.Denny, Brian D.Palmer

Tags: Bedaquiline (TMC-207), Drug Discovery, M.tb. Biology

Tuberculosis and antimicrobial resistance - new models of research and development needed

5/2017 - Bulletin of the World Health Organization

Author(s): Brigden G, Castro JL, Ditiu L, Gray G, Hanna D, Low M, Matsoso MP, Perry G, Spigelman M, Swaminathan S, Torreele E, Wong S

Tags: MDR-TB, TB Burden, XDR-TB

The impact of HIV and antiretroviral therapy on TB risk in children: A systematic review and meta-analysis

1/2017 - Thorax Online, 23 Jan. 2017. Web. 31 Jan. 2017.

Author(s): Dodd, P. J., A. J. Prendergast, C. Beecroft, B. Kampmann, and J. A. Seddon. "The Impact of HIV and Antiretroviral Therapy on TB Risk in Children: A Systematic Review and Meta-analysis."

Tags: Childhood TB, Clinical Trial Results, TB-HIV

TB Alliance regimen development for multidrug-resistant tuberculosis

12/2016 - The International Journal of Tuberculosis and Lung Disease

Author(s): Murray, S., Mendel, C., & Spigelman, M.

Tags: Linezolid, MDR-TB, NC-005, Nix-TB, STAND/NC-006

Tuberculosis

10/2016 - Tuberculosis.Nature Reviews Disease Primers. 2016/10/27/online. 16076. Macmillan Publishers Limited. http://dx.doi.org/10.1038/nrdp.2016.76

Author(s): Pai, Madhukar; Behr, Marcel A.; Dowdy, David; Dheda, Keertan; Divangahi, Maziar; Boehme, Catharina C.; Ginsberg, Ann; Swaminathan, Soumya; Spigelman, Melvin; Getahun, Haileyesus; Menzies, Dick; Raviglione, Mario

Tags: Clinical Development, Drug Discovery, MDR-TB, TB-HIV

Population-based resistance of Mycobacterium tuberculosis isolates to pyrazinamide and fl uoroquinolones: results from a multicountry surveillance project

7/2016 - Zignol, Matteo, Anna Dean, and Natavan Alikhanova. "Population-based Resistance of Mycobacterium Tuberculosis." The Lancet (Published Online July 7, 2016 Http://dx.doi.org/10.1016/S1473-3099(16)30190-6):

Tags: Drug-Sensitivity Testing, MDR-TB, Moxifloxacin, Pyrazinamide, TB Burden

Developing a Framework for Evaluating Ethical Outcomes of Good Participatory Practices in TB Clinical Drug Trials

6/2016 - Journal of Empirical Research on Human Research Ethics 1556264616657452, first published on June 30, 2016 doi:10.1177/1556264616657452

Author(s): Kathleen M. MacQueen, Natalie T. Eley, Mike Frick, Laia Ruiz Mingote, Alicia Chou, Stephanie S. Seidel, Stacey Hannah, and Carol Hamilton

Tags: Advocacy, Clinical Development, Community Engagement, TB-HIV, Trial Design

Global burden of drug-resistant tuberculosis in children: a mathematical modelling study

6/2016 - Peter J Dodd, Charalambos Sismanidis, James A Seddon. Global burden of drug-resistant tuberculosis in children: a mathematical modelling study. The Lancet Infectious Diseases , Volume 0 , Issue 0

Tags: Childhood TB, MDR-TB, TB Burden, XDR-TB

Grand Convergence: Aligning Technologies & Realities in Global Health

3/2016 - Yamey G, Morel C. Investing in Health Innovation: A Cornerstone to Achieving Global Health Convergence. PLOS Biology. 2016 Mar 1;14(3). doi: 10.1371/journal.pbio.1002389.

Tags: Advocacy, Editorials, Policy, TB Burden

The Zika Loopholes: The FDA has a smart-sounding program to drive research for neglected diseases—with two big flaws

3/2016 - Brock WR, Cohen R, Cone J, McKenna L. The Zika Loopholes: The FDA.... March 25, 2016. http://www.politico.com/agenda/story/2016/03/the-right-way-to-encourage-companies-to-develop-a-treatment-for-zika-000079. Accessed March 25, 2016.

Tags: Editorials

"Understanding and addressing the tuberculosis case detection gap national inventory studies to improve estimates of incidence and strengthen surveillance" with comments

3/2016 - Sismanidis C, Glaziou P, Bloss E, et. al. "Understanding and addressing the tuberculosis case detection gap national inventory studies to improve estimates of incidence and strengthen surveillance" with comments. 2016 Mar

Tags: Advocacy, Editorials, MDR-TB, Policy, TB Burden, TB Drug Market, TB Market

Understanding and addressing the tuberculosis case detection gap national inventory studies to improve estimates of incidence and strengthen surveillance

3/2016 - Sismanidis C, Glaziou P, Bloss E, et. al. Understanding and addressing the tuberculosis case detection gap national inventory studies to improve estimates of incidence and strengthen surveillance. 2016 Mar.

Tags: Advocacy, Editorials, MDR-TB, Policy, TB Burden, TB Drug Market, TB Market

Investing in Health Innovation: A Cornerstone to Achieving Global Health Convergence

3/2016 - Yamey G, Morel C. Investing in Health Innovation: A Cornerstone to Achieving Global Health Convergence. PLOS Biology. 2016 Mar 1;14(3). doi: 10.1371/journal.pbio.1002389.

Tags: Advocacy, Editorials, Policy, TB Burden

Drug-resistant tuberculosis clinical trials: proposed core research definitions in adults

3/2016 - Furin J., Alirol E, Allen E, et. al. Drug-resistant tuberculosis clinical trials: proposed core research definitions in adults. Int J Tuberc Lung Dis. 20161 Mar; 20(3): 290-294.

Tags: Clinical Development, Editorials, MDR-TB, Trial Design, XDR-TB

Limited role of culture conversion for decision-making in individual patient care and for advancing novel regimens to confirmatory clinical trials

3/2016 - Phillips PPJ, Mendel CM, Burger DA, et al. Limited role of culture conversion for decision-making in individual patient care and for advancing novel regimens to confirmatory clinical trials. BMC Medicine. 2016 Mar.14:19. doi: 10.1186/s12916-016-0565-y

Tags: Biomarkers, Clinical Development, Moxifloxacin, ReMoxTB, Trial Design

The pharmacokinetics of rifampicin, isoniazid, pyrazinamide and ethambutol in infants dosed at revised WHO-recommended treatment guidelines

1/2016 - Bekker A, Schaaf HS, Murray S, et. al. The pharmacokinetics of rifampicin, isoniazid, pyrazinamide and ethambutol in infants... Antimicrob Agents Chemother. 2016 Jan 25. pii: AAC.02600-15. doi: 10.1128/aac.02600-15.

Tags: Childhood TB, Clinical Trial Results, HRZE, Pharmacokinetics, Pyrazinamide

The procurement landscape of pediatric tuberculosis treatment: a Global Drug Facility perspective

12/2015 - Scott C, Gardiner E, de Lucia A. The procurement landscape of pediatric tuberculosis treatment: a Global Drug Facility perspective. Int J Tuberc Lung Dis. 2015 Dec;19 Suppl 1:17-22. doi: 10.5588/ijtld.15.0478.

Tags: Advocacy, Childhood TB, Policy, Regimen Change, TB Burden, TB Drug Market, TB Market

Pediatric tuberculosis drug market: an insider perspective on challenges and solutions

12/2015 - Usherenko I, Basu Roy U, Mazlish S, et. al. Pediatric tuberculosis drug market: an insider perspective on challenges and solutions. Int J Tuberc Lung Dis. 2015 Dec;19 Suppl 1:23-31. doi: 10.5588/ijtld.15.0479.

Tags: Advocacy, Childhood TB, Policy

Paediatric formulations of second-line anti-tuberculosis medications: challenges and considerations

12/2015 - Taneja R, Garcia-Prats AJ, Furin J, Maheshwari HK. Paediatric formulations of second-line anti-tuberculosis medications: challenges and considerations. Int J Tuberc Lung Dis. 2015 Dec;19 Suppl 1:61-8. doi: 10.5588/ijtld.15.0435.

Tags: Advocacy, Childhood TB, Editorials, MDR-TB, Regimen Change

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